In most countries, internationally indexed scientific publications provide the possibility for the scientometric experts to study their scientific progress. In Iran, the number of scientific productions indexed in ISI was 323 in 1993 and rose to 14832 in 2008 showing about 46 manifolds. The main aim of this research is to illustrate the dynamic structure of scientific productions of Iranian biotechnologists and applied microbiologists in WOS database during 2000–2008. The data was gathered through searching WOS database of ISI. The field of search was country (CU=IRAN). 681 scientific products were reported to be indexed in ISI. Iranians' international collaboration has been mainly with Canadian, Swedish and Australian coauthors. Compared to other Iranian universities, University of Tehran, Tarbiat Modares University and Tehran University of Medical Sciences have contributed mostly to ISI. Iranian biotechnologists’ and microbiologists’ intercontinental collaboration is generally in Biochemistry and Molecular Biology, Engineering and chemical and Biochemical research. There has been an increase in the fundamental research activities in Biotechnology and Applied Microbiology research projects which have triggered motivation for higher contribution to ISI.